Conventional immunosuppression and co-stimulation blockade.

摘要: Organ transplantation has become an accepted and successful therapeutic intervention for many patients with end-stage organ disease. Current conventional immunosuppressive regimens achieve very good short-term allograft survival but long-term outcomes are less than adequate. Furthermore, non-specific immunosuppression its attendant side-effects including increased risks of malignancy infection as well drug-specific sequellae. With recent advances in the field immunology, promising new therapies have arisen that could potentially eliminate lifelong drug therapy promote indefinite acceptance donor tissue. Identification co-stimulatory signals essential T-cell activation provided exciting possibilities controlling alloimmune response. The compatibility these agents proven therapeutics yielded mixed results. When used combination, their properties appear synergistic. However, if goal is sustained, specific hyporesponsiveness, antagonize effects blockade several immune tolerance models.