Sex differences in the response of rats to pentobarbital sodium

摘要: Abstract 1.1. Pentobarbital disappears from the blood of pregnant rats relatively more slowly than nonpregnant females. From eighth through twelfth hour after injection level remains significantly higher in animal. 2.2. Brain levels remain rat sixth hour. Two to 4 hours fetal brain are 90 per cent maternal values and up 12 approximately 75 that mother. 3.3. Similarly, drug liver rat. Fetal has a slightly affinity for barbiturate does brain. It is doubtful, however, contains enzymes capable detoxifying drug. 4.4. also present small amounts amniotic fluid, but its disappearance this site slower tissues. 5.5. Thus, when female given drug, brunt detoxification falls upon at once. The respiratory, circulatory, temperature regulatory mechanisms severely depressed until achieved within few hours, drugged awakens early. 6.6. In rat, on other hand, not receive full burden as rapidly. crosses placental barrier pools tissues only be fed back into gradually. play no role detoxification, merely serve decrease load thrown mother one time. high sleep prolonged. 7.7. light pregnancy, failure become enigmatic. A possible cause could lie alterations protein-binding pregnancy. 8.8. unknowns solved: (1) Is assumption incapable valid neonatal rabbits, guinea pigs, mice? (2) To what degree pentobarbital altered pregnancy?