Malignancies After Transplantation and Posttransplant Lymphoproliferative Disorder

摘要: Renal transplantation is the preferred mode of renal replacement therapy providing best outcome in terms patient morbidity and mortality. In 2010, more than 16,000 kidney transplants were performed United States. Although short-term outcomes graft survival are uniformly outstanding, long-term continue to be less optimal. The leading cause late allograft loss death with a functioning allograft. While primary remains as cardiovascular disease, malignancy now second post transplantation. Indeed, cancer has an overall two- fourfold elevated risk incidence compared healthy, non-transplanted individuals. development transplant recipient substantially increases by much fourfold, which further enhanced older age male gender. Moreover, immunosuppressive burden may critical feature pathogenesis another argument for avoidance minimization protocols. Posttransplant classified into one three categories: recurrence preexisting rare but definable donor-transmitted malignancy, finally de novo malignancy. this chapter, we will review each these types cancers, evaluating management. increased accompanied substantial early necessitates need careful pre-transplantation screening, detection after transplantation, appropriate