The PGC-1α-dependent pathway of mitochondrial biogenesis is upregulated in type I endometrial cancer
作者： Antonella Cormio , Flora Guerra , Gennaro Cormio , Vito Pesce , Flavio Fracasso
DOI: 10.1016/J.BBRC.2009.10.114
关键词:
摘要: PGC-1α-dependent pathway of mitochondrial biogenesis was investigated for the first time in type I endometrial cancer and normal endometrium. In tissue citrate synthase activity, DNA content TFAM level were found doubled compared to control tissue. Moreover, a 1.6- 1.8-fold increase, respectively, NRF-1 PGG-1α expression found. This study demonstrates, time, that increased is associated upregulation PGC-1α signalling pathway.
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