Molecular profiling of malignant pleural mesothelioma and pulmonary fibrosis
作者： Pamela Lindholm
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摘要: 5 I REVIEW OF THE LITERATURE 8 1 ASBESTOS FIBRES 1.1.1 Oxidative stress and antioxidant pathways 11 1.1.2 Nuclear factor-kappa B (NFB) tumor necrosis factor(TNF) 13 1.1.3 Epidermal growth factor receptor (EGFR) mediated pathway 14 1.1.4 Transforming factor(TGF) 2 MALIGNANT MESOTHELIOMA (MM) 15 2.2.1 DNA copy number changes in MM 19 3 IDIOPATHIC PULMONARY FIBROSIS (IPF) 28 3.1.1 factor– (TGF) 31 3.1.2 Bone morphogenetic proteins (BMPs) gremlin 32 4 HIGH-RESOLUTION PROFILING METHODS IN FINDING MARKERS FOR DETECTION DISEASES 35 1.1 Genes affected by asbestos fibres 9 1.2 Asbestos-related diseases 2.1 Histological classification of 17 2.2 Molecular genetics pathology 18 2.3 Diagnoses prognosis patients 23 2.4 therapy options, treatment resistance 25 3.2 Diagnosis lung fibrosis 34 4.1 Microarray platforms 4.2 Asbestos associated signatures 36
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