Increased expression of soluble inducible costimulator ligand (ICOSL) in patients with systemic lupus erythematosus.

摘要: To investigate the level of costimulating molecules in systemic lupus erythematosus (SLE), we assessed plasma concentrations soluble forms costimulatory such as programmed death-1 (PD-1), B7-H1 (also called PD-L1 or CD274) and inducible costimulator ligand (ICOSL) patients with SLE. Plasma PD-1, ICOSL were measured by ELISA using samples from 57 SLE without active disease, 21 rheumatoid arthritis (RA) 35 healthy subjects. We also evaluated surface expression on B cells flow cytometry to gain a better understanding expression. compare mRNA expression, reverse transcriptase-polymerase chain reaction (RT-PCR) was performed total RNA peripheral blood mononuclear (PBMCs) isolated eight subjects 11 The concentration significantly higher compared (P = 0.005)...