Polymorphisms of genes for programmed cell death 1 ligands in patients with rheumatoid arthritis.
作者： Shu-Chen Wang , Chia-Hui Lin , Ruei-Nian Li , Tsan-Teng Ou , Cheng-Chin Wu
DOI: 10.1007/S10875-007-9113-Z
关键词:
摘要: To investigate the role of ligands for programmed cell death 1 (PD-L) in pathogenesis rheumatoid arthritis (RA), 129 patients with RA and 125 unrelated healthy controls were enrolled this study. The PD-L1 PD-L2 polymorphisms determined by method polymerase chain reaction (PCR)/direct sequencing or PCR/reaction fragment length polymorphisms. genotype distributions 6777 C/G not significantly different between controls. There was also no significant difference allele frequencies Similar findings could be found phenotypes alleles 47103 C/T 47139 T/C G had higher prevalence nodule comparison those without (p = 0.005, OR 4.0, 95% CI 1.5–10.9). In contrast, related to occurrence nodule. This study demonstrated that associated susceptibility Taiwan.
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