Vaginal misoprostol administration for cervical ripening and labor induction.

摘要: Intravaginal misoprostol has been shown to be an effective agent for cervical ripening and induction of labor. Vaginal application reported in over 9000 women worldwide seems have safety profile similar that endocervically intravaginally administered dinoprostone. Concern arises with the use higher doses intravaginal (50 mcg or more) association uterine contractile abnormalities this reason, low-dose regimen recommended by American College Obstetricians Gynecologists. The recommendation is a 25-mcg dose inserted into posterior vaginal fornix repeated every 3 6 hours as needed. Misoprostol administration prior cesarean births increase likelihood scar disruption should not used these women. There are reports rupture unscarred uteri treated vaginally applied misoprostol. Therefore, all patients need monitored adequately after administration. Although there growing body data regarding ambulatory ripening, its purpose cannot outside investigational protocols at time because concerns maternal neonatal safety.