摘要: Overview of DNA Repair Pathways Longevity Assurance by Genome Maintenance Instability Cancer: Biological Predictions and Clinical Implications Radiation Induced Damage, Therapeutics Chemotherapeutic Alkylating Agents in Cancer Treatment O6-Methylguanine-DNA Methyltransferase (MGMT) Protection Therapy Mismatch Repair: It's Role Human Carcinogenesis as a Predictive and/or Prognostic Biomarker for Base Excision Therapeutics: Summary Targets with Focus on APE1 Nucleotide Capacity Variability Susceptibility Fanconi Anemia, Interstrand Cross-link Functions Translesion Polymerases: Risk Opportunities Therapeutic p53 ATM/ATR Cell Cycle Checkpoints: Mechanisms Manipulation The BRCA1-BRCA2 Pathway Homologous Recombination the Opportunity Synthetic Lethal Approaches to PARP Inhibitor Tumor Genetics Personalized Medicine Microenvironment Progression Early Phase Trials using Inhibitors: Lessons Learnt