Small-molecule inhibitors of histone deacetylase for the treatment of cancer and non-cancer diseases: a patent review (2011 – 2013)
作者： Sergio Valente , Antonello Mai
DOI: 10.1517/13543776.2014.877446
关键词:
摘要: Introduction: Histone deacetylases (HDACs) play an important role in mediating the expression of genes involved cancer and non-cancer diseases. Overexpression these enzymes has been shown several types some enzyme isoforms were described as responsible for neurological inflammatory pathologies, hence use HDAC inhibitors represents a strategy their treatment. Different chemical entities have developed recent years them entered clinical trials. Areas covered: This review accounts small-molecule reported patent literature covering 2011 – 2013 period, potential therapeutics cancer, Expert opinion: The development isoform-selective to avoid side effects therapy, fight specific or diseases is ongoing but still needs many scientific efforts. Moreover, using...
core.ac.uk
sci-hub.se 参考文章(59)
Changsik Lee, Hyun-Mo Yang, Dal-Hyun Kim, Yuntae Kim, Jaeki Min, Hyojin Lim, Soyoung Kim, Jung-Min Kim, Nina Ha, Eunhee Ko, Hojin Choi, Hydroxamate derivatives for hdac inhibitor, and the pharmaceutical composition comprising thereof ,(2012)
Aizpea Zubia Olascoaga, María del Carmen Masdeu Margalef, Eider Ion San Sebastián Larzabal, Fernando Pedro Cossío Mora, Yosu Vara Salazar, Dorleta Otaegui Ansa, Eneko Aldaba Arévalo, New histone deacetylase inhibitors based simultaneously on trisubstituted 1h-pyrroles and aromatic and heteroaromatic spacers ,(2010)
Ignacio Munoz-Sanjuan, Roland W. Burli, John E. Mangette, Andrew J. Stott, Alan F. Haughan, Celia Dominguez, Perla Breccia, Christopher A. Luckhurst, Samantha J. Hughes, Histone deacetylase inhibitors and compositions and methods of use thereof ,(2014)
Daniel Antunes Moreno, Carlos Alberto Scrideli, Maria Angélica Abdala Cortez, Rosane de Paula Queiroz, Elvis Terci Valera, Vanessa Da Silva Silveira, José Andres Yunes, Silvia Regina Brandalise, Luiz Gonzaga Tone, None, Differential expression of HDAC3, HDAC7 and HDAC9 is associated with prognosis and survival in childhood acute lymphoblastic leukaemia. British Journal of Haematology. ,vol. 150, pp. 665- 673 ,(2010) , 10.1111/J.1365-2141.2010.08301.X
Davide Vignola, Loredana Vesci, Walter Cabri, Nicola Fanto, Gianfranco Battistuzzi, Claudio Pisano, Giuseppe Giannini, New thio derivatives bearing lactams as potent hdac inhibitors and their uses as medicaments ,(2012)
Adegboyega Oyelere, Berkley Gryder, Histone deacetylase (hdac) inhibitors targeting prostate tumors and methods of making and using thereof ,(2011)
Changgeng Qian, Rudi Bao, Chengjung Lai, Treatment of cancers having k-ras mutations ,(2011)
Hilal Özdağ, Andrew E Teschendorff, Ahmed Ashour Ahmed, Sarah J Hyland, Cherie Blenkiron, Linda Bobrow, Abhi Veerakumarasivam, Glynn Burtt, Tanya Subkhankulova, Mark J Arends, V Peter Collins, David Bowtell, Tony Kouzarides, James D Brenton, Carlos Caldas, None, Differential expression of selected histone modifier genes in human solid cancers BMC Genomics. ,vol. 7, pp. 90- 90 ,(2006) , 10.1186/1471-2164-7-90
Mario Varasi, Florian Thaler, Saverio Minucci, Raffaella Amici, Agnese Abate, Ciro Mercurio, Maria Carmela Fulco, Spirocyclic derivatives as histone deacetylase inhibitors ,(2009)
María del Carmen Masdeu Margalef, Eneko Aldaba Arévalo, Yosu Ion Vara Salazar, Eider San Sebastián Larzabal, Sergio Villafruela Cáneva, Fernando Pedro Cossío Mora, María Remedios Alcalá Caffarena, Dorleta Otaegui Ansa, Maialen Aginagalde Unanue, Aizpea ZUubia Olascoaga, Hydroxyphenyl pyrrole compounds containing an hydroxamic acid as hdac inhibitors and medicinal applications thereof ,(2012)