Subjective memory decline predicts greater rates of clinical progression in preclinical Alzheimer's disease
作者： Rachel F. Buckley , Paul Maruff , David Ames , Pierrick Bourgeat , Ralph N. Martins
DOI: 10.1016/J.JALZ.2015.12.013
关键词:
摘要: Abstract Introduction The objective of this study was to determine the utility subjective memory decline (SMD) predict episodic change and rates clinical progression in cognitively normal older adults with evidence high β-amyloid burden (CN Aβ+). Methods Fifty-eight CN Aβ+ participants from Australian Imaging, Biomarkers, Lifestyle responded an SMD questionnaire underwent comprehensive neuropsychological assessments. Participant data for three follow-up assessments were analyzed. Results In Aβ+, subjects did not exhibit significantly greater than those low SMD. High related mild cognitive impairment or Alzheimer's disease (AD) dementia (hazard ratio = 5.1; 95% confidence interval, 1.4–20.0, P = .02) compared associated depressive symptomatology smaller left hippocampal volume. Discussion is a harbinger preclinical AD. Although reflects broader diagnostic implications more sensitive measures may be required detect early subtle change.
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