Development of Sr and CO3 co-substituted hydroxyapatites for biomedical applications.

摘要: Sr and CO3 co-substituted hydroxyapatite (SrCHA) nanopowder was synthesized by neutralization. The powder characterized. improved solubility in Hanks' balanced solution of SrCHA granules (400-600 microm dimensional range), potentially usable as bone filler, assessed compared with that an analogous carbonate free granulate. porous bodies interconnected micro- macro-porosity, which mimic the morphology spongy bone, were prepared impregnation cellulose sponges suspensions controlled sintering. scaffolds sintered at 850 degrees C, flowing CO2 atmosphere, showed satisfying compressive strength (4.58+/-0.75 MPa) for a porosity value 45 vol.% retained desired ionic substitutions (Sr/Ca=0.11 CO3=6.8 wt.%). possibility widely modulating, acting on chemical-physical-geometrical features material, prolonged situ release therapeutic Sr, together fundamental (Ca, PO4) main substituting (CO3) ions constitute mineral phase, makes use resorbable filler or substitute promising, especially when pathologies related deficiency are present. In vitro vivo tests progress.