The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses
作者： Guillaume Assié , Marine Guillaud-Bataille , Bruno Ragazzon , Xavier Bertagna , Jérôme Bertherat
DOI: 10.1016/J.TEM.2009.12.009
关键词:
摘要: Analyzing gene expression (transcriptome) in tissue is now reliable using industrial pangenomic microarrays. Accumulating data on adrenal cortex and adrenocortical tumor transcriptomes have already identified striking transcriptome differences not only between adenoma carcinoma but also two sets of carcinoma, which very different prognoses. These findings result the development diagnostic prognostic molecular predictors, improve outcome determination compared with standard clinical pathological tools. observing phenotype great complex detail, combined genomic proteomic information, will function for future research investigating pathophysiology their tumorigenesis hormonal secretion.
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