Inhibitory potential of phenylpropanoid glycosides from Ligustrum purpurascens Kudingcha against α‐glucosidase and α‐amylase in vitro

摘要: Summary The leaves of Ligustrum purpurascens are used in a Chinese traditional tea called small-leaved kudingcha, which is rich phenylpropanoid glycosides (PPGs) and has many beneficial properties. Two critical exoacting glycoside hydrolase enzymes (glucosidases) involved carbohydrate digestion α-glucosidase α-amylase. We investigated the properties PPGs from L. purpurascens for inhibiting α-amylase activity in vitro found IC50 values 1.02 0.73 mg mL−1, respectively. The patterns both were mixed-inhibition type. Multispectroscopy molecular docking studies indicated that interaction between altered conformation enzymes, with binding at site close to active resulting changed enzyme activity. Our may help further health use kudingcha.