Childhood maltreatment predicts reduced inhibition-related activity in the rostral anterior cingulate in ptsd, but not trauma-exposed controls

摘要: BACKGROUND: A deficit in the ability to inhibit fear has been proposed as a biomarker of posttraumatic stress disorder (PTSD). Previous research indicates that individuals with PTSD show reduced inhibition-related activation rostral anterior cingulate cortex (rACC). The goal current study was investigate differential influences an early environmental risk factor for PTSD-childhood maltreatment-on brain function versus trauma-exposed controls. METHODS: Individuals (n = 37) and controls 53) were recruited from primary care waiting rooms urban public hospital Atlanta, GA. Participants completed inhibition task during fMRI, reported childhood adult traumatic experiences. groups matched child trauma load. RESULTS: We observed interaction between maltreatment severity status rACC (P CONCLUSIONS: Findings highlight individual differences neural following trauma, point ACC PTSD.© 2016 Wiley Periodicals, Inc. Language: en