Neuroendocrine peptides of the gastrointestinal tract of an animal model of human type 2 diabetes mellitus.

摘要: We studied ten obese diabetic mice (Umea/ Bom-ob) and 10 homozygous lean controls aged 21 weeks. The concentration of several neuroendocrine peptides was determined by radioimmunoassay tissue extracts antrum, duodenum distal colon. that we investigated were: secretin, gastric inhibitory polypeptide (GIP), gastrin, motilin, peptide YY (PYY), somatostatin, vasoactive intestinal (VIP), substance P, neurotensin, neuropeptide Y (NPY) galanin. In the VIP, P NPY concentrations were significantly lower in than controls. There no statistical difference between for neurotensin galanin content. duodenum, mice. regarding GIP, or colon, levels PYY, did not differ from present study showed system is disturbed an animal model human type 2 diabetes this disturbance differs observed other models 1 diabetes. findings may have some implications gastrointestinal dysfunction patients with