Curcumin (Diferuloylmethane) induces apoptosis and blocks migration of human medulloblastoma cells.
作者： Sanjay Kansra , Madhavi Latha Yadav Bangaru , Shenglin Chen , Jeffrey Woodliff
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摘要: Medulloblastoma (MB) is the most common malignant brain tumor in children. Bcl-2 and MMP-9 promote pathogenesis progression of MB. The expression both bcl-2 regulated by transcription factor NF-kappaB. Curcumin, a natural food additive, has potent anti-proliferative effect, presumably mediated through NF-kappaB suppression. tumor-suppressing effects curcumin are well documented, however, its effect on MB unknown. Our objectives were to: a) examine cell proliferation apoptosis; b) characterize mechanism that mediates curcumin; c) migration. We report inhibited blocked clonogenicity cells. Furthermore, down-regulated bcl(x)l, leading to caspase-mediated death. Finally, migration Thus, we propose developing as novel therapeutic agent for
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