Curcumin-induced HDAC inhibition and attenuation of medulloblastoma growth in vitro and in vivo
作者： Seung Joon Lee , Candice Krauthauser , Victoria Maduskuie , Paul T Fawcett , James M Olson
关键词:
摘要: Background Medulloblastoma is the most common brain tumor in children, and its prognosis worse than for many other pediatric cancers. Survivors undergoing treatment suffer from serious therapy-related side effects. Thus, it imperative to identify safer, effective treatments medulloblastoma. In this study we evaluated anti-cancer potential of curcumin medulloblastoma by testing ability induce apoptosis inhibit growth vitro vivo using established models.
biomedcentral.com
springer.com
core.ac.uk
paperity.org参考文章(54)
Anne-Laurence Boutillier, Emmanuelle Trinh, Jean-Philippe Loeffler, Selective E2F‐dependent gene transcription is controlled by histone deacetylase activity during neuronal apoptosis Journal of Neurochemistry. ,vol. 84, pp. 814- 828 ,(2003) , 10.1046/J.1471-4159.2003.01581.X
Joan S. Steffan, Laszlo Bodai, Judit Pallos, Marnix Poelman, Alexander McCampbell, Barbara L. Apostol, Alexsey Kazantsev, Emily Schmidt, Ya-Zhen Zhu, Marilee Greenwald, Riki Kurokawa, David E. Housman, George R. Jackson, J. Lawrence Marsh, Leslie M. Thompson, Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila Nature. ,vol. 413, pp. 739- 743 ,(2001) , 10.1038/35099568
Sanjay Kansra, Madhavi Latha Yadav Bangaru, Shenglin Chen, Jeffrey Woodliff, Curcumin (Diferuloylmethane) induces apoptosis and blocks migration of human medulloblastoma cells. Anticancer Research. ,vol. 30, pp. 499- 504 ,(2010)
R. L. Yauch, G. J. P. Dijkgraaf, B. Alicke, T. Januario, C. P. Ahn, T. Holcomb, K. Pujara, J. Stinson, C. A. Callahan, T. Tang, J. F. Bazan, Z. Kan, S. Seshagiri, C. L. Hann, S. E. Gould, J. A. Low, C. M. Rudin, F. J. de Sauvage, Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma Science. ,vol. 326, pp. 572- 574 ,(2009) , 10.1126/SCIENCE.1179386
E. Hockly, V. M. Richon, B. Woodman, D. L. Smith, X. Zhou, E. Rosa, K. Sathasivam, S. Ghazi-Noori, A. Mahal, P. A. S. Lowden, J. S. Steffan, J. L. Marsh, L. M. Thompson, C. M. Lewis, P. A. Marks, G. P. Bates, Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 2041- 2046 ,(2003) , 10.1073/PNAS.0437870100
Jessica E. Bolden, Melissa J. Peart, Ricky W. Johnstone, Anticancer activities of histone deacetylase inhibitors Nature Reviews Drug Discovery. ,vol. 5, pp. 769- 784 ,(2006) , 10.1038/NRD2133
Ulrich Schüller, Vivi M. Heine, Junhao Mao, Alvin T. Kho, Allison K. Dillon, Young-Goo Han, Emmanuelle Huillard, Tao Sun, Azra H. Ligon, Ying Qian, Qiufu Ma, Arturo Alvarez-Buylla, Andrew P. McMahon, David H. Rowitch, Keith L. Ligon, Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Shh-induced medulloblastoma. Cancer Cell. ,vol. 14, pp. 123- 134 ,(2008) , 10.1016/J.CCR.2008.07.005
M Martin, R Kettmann, F Dequiedt, Class IIa histone deacetylases: regulating the regulators Oncogene. ,vol. 26, pp. 5450- 5467 ,(2007) , 10.1038/SJ.ONC.1210613
Nilanjan Sengupta, Xiaohong Zhang, Edward Seto, Michele A. Glozak, Acetylation and deacetylation of non-histone proteins Gene. ,vol. 363, pp. 15- 23 ,(2005) , 10.1016/J.GENE.2005.09.010
Nazanin Majdzadeh, Lulu Wang, Brad E. Morrison, Rhonda Bassel-Duby, Eric N. Olson, Santosh R. D'Mello, HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Developmental Neurobiology. ,vol. 68, pp. 1076- 1092 ,(2008) , 10.1002/DNEU.20637