Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges

摘要: The term “epigenetics” refers to modifications in gene expression caused by heritable, but potentially reversible, changes DNA methylation and chromatin structure. Epigenetic alterations have been identified as promising new targets for cancer prevention strategies they occur early during carcinogenesis represent initiating events development. Over the past few years, nutri-epigenetics – influence of dietary components on mechanisms influencing epigenome has emerged an exciting field current epigenetic research. During carcinogenesis, major cellular functions pathways, including drug metabolism, cell cycle regulation, potential repair damage or induce apoptosis, response inflammatory stimuli, signalling, growth control differentiation become deregulated. Recent evidence now indicates that contribute these defects, example silencing detoxifying enzymes, tumor suppressor genes, regulators, apoptosis-inducing nuclear receptors, signal transducers transcription factors promoter methylation, histones non-histone proteins such p53, NF-κB, chaperone HSP90 acetylation methylation.