Autoimmune paraneoplastic cerebellar degeneration secondary to a composite lymphoma

摘要: Paraneoplastic cerebellar degeneration (PCD) is a disabling neurological condition that occurs in 0.5% of patients diagnosed with Hodgkin lymphoma (HL) [1]. The dysfunction associated the presence Tr antibodies but it not clear whether these autoantibodies are pathogenic. Treatment comprises underlying uniform improvement symptoms. In 1% cases, HL association B-lymphoproliferative disorder (BPLD) found either lymph node involved or bone marrow, such dual pathology being termed composite [2]. We describe case whose diagnosis was preceded by PCD and which successfully treated novel combination Rituximab multiagent chemotherapy consisting Adriamycin, Bleomycin, Vinblastine Dacarbazine. A 47-year-old man admitted 3-week history progressive dizziness, dysarthria ataxia. Clinical examination revealed signs left syndrome evidenced horizontal nystagmus, ataxia tendency to fall left, dysmetria. There no lympadenopathy organomegaly. Haematological biochemical testing unremarkable except for raised serum alkaline phosphate plasma viscosity. Magnetic resonance imaging brain normal ischemic damage. Cerebrospinal fluid (CSF) analysis 57 leucocytes/mm 3 (40% lympho