Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin's lymphoma.

摘要: ABsTrACTparaneoplastic cerebellar degeneration (pCd) can present as a severe and (sub)acute syndrome. pCd accompany different kinds of neoplasms including small cell lung cancer, adenocarcinoma the breast ovary, hodgkin’s lymphoma. A 34-year-old patient is described with acute dysarthria, gait ataxia diplopia. despite extensive laboratory radiological evaluations in this rapidly deteriorating syndrome, diagnosis paraneoplastic syndrome was only made after several months, when an anti-Tr antibody detected his serum. The search for disease concomitant disorder then started resulted stage iiB disease. successively treated six courses etoposide, bleomycin, vinblastine dexamethasone radiotherapy, which complete remission After starting therapy stabilised. pathogenesis neuronal damage central nervous system disorders such one we describe not completely understood. Antitumour assumed to be important cornerstone stabilising neurological condition. improvement autoantibody rare achievement. Early recognition (anti-Tr lymphoma) crucial importance. KEywordsAnti-Tr, degeneration, Hodgkin’s lymphoma, paraneoplasticiNTroduCTioNParaneoplastic (PCD) typically presents (sub)acute, ataxia.