Familial Clustering of Gastric Cancer: A Retrospective Study Based on the Number of First-Degree Relatives

摘要: This comprehensive cross-sectional study aimed to identify factors contributing familial aggregation of gastric cancer (GC). A total 1058 GC patients and 1268 controls were analyzed separately according the presence or absence a first-degree relative (GC-relative). Logistic regression analysis adjusted for age, gender, residence during childhood, smoking, alcohol intake, monthly income, spicy food ingestion, Helicobacter pylori status host cytokine polymorphisms was performed. Cytotoxin-associated gene (cagA) positivity distinctive risk factor in family history (FH)-positive group (odds ratio [OR], 2.39; 95% confidence interval [CI], 1.42–4.00), while current/ex-smoker, moderate strong non-B blood types more closely associated with FH-negative group. Among FH-positive group, consumption showed synergistic carcinogenic effect at least 2 GC-relatives compared 1 GC-relative (1.71 vs. 9.58, P interaction = 0.026), this dose-dependent. In subjects ≥2 GC-relatives, TGFB1-509T/T (OR 23.74; CI 1.37–410.91), as rural residency consumption, cagA positivity. These results suggest that FH may be heterogeneous terms susceptibility. Especially, should undergo stratification including consumption.