BCL-2 proto-oncogene expression in prostate cancer and its relationship to the prostatic neuroendocrine cell.

摘要: Abstract Prostatic adenocarcinoma has a divergent response to androgen ablation and varied long-term prognosis. BCL-2 is proto-oncogene that prevents programmed cell death. Since withdrawal induces apoptosis, it been postulated may play role in resistance. Neuroendocrine cells have demonstrated prostate cancer an adverse influence on This study demonstrates proportional relationship between the tissue levels of neuroendocrine marker, neuron-specific enolase 11 13 cases primary cancer. does not appear exist metastatic or most nonprostate cancers. Direct immunohistochemical staining confirmed six tumors, these BCL-2-containing appeared be intimately associated with tumor cells.