Neuroendocrine Differentiation in Prostate Cancer
作者： Renato Franco , Paolo Chieffi , Sisto Perdonà , Gaetano Facchini , Michele Caraglia
DOI: 10.1007/978-94-007-7149-9_5
关键词:
摘要: Neuroendocrine differentiation (ND) is widely observed in prostate cancer (PC). Its role clinical practice controversial, but preclinical and evidences underline the association of ND with poor prognosis PC patients. (NE) cells could condition progression, mainly stimulating exocrine neoplastic proliferation through production paracrine growth factors. Thus, castrated adapted are favored to outgrowth an androgen receptor independent mechanism. Moreover proportion NE increases because tumor treatment, deprivation therapy, enormously amplifying promotion component stimulated by neuroendocrine
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