Synthesis and hplc chiral recognition of regioselectively carbamoylated cellulose derivatives

摘要: Four regioselective-carbamoylated cellulose derivatives having two different substituents at 2-, 3-, and 6-position were prepared evaluated as chiral stationary phases (CSPs) for high-performance liquid chromatography. Investigations showed that the nature andarrangement of significantly influenced recognition abilities heterosubstituted each derivative exhibited characteristic enantioseparation. Some racemates better resolved on these than corresponding homogeneously substituted including a commercial CSP, Chiralcel OD. Racemic compounds shown in this study most effectively discriminated cellulose2,3-(3-chloro-4-methylphenylcarbamate)-6-(3,5-dimethylphenylcarbamate) 2,3-(3,5-dimethylphenylcarbamate)-6-(3-chloro-4-methylphenylcarbamate). Chirality, 2012. © 2011 Wiley Periodicals, Inc.