The VITA project: C677T mutation in the methylene-tetrahydrofolate reductase gene and risk of venous thromboembolism

摘要: We evaluated the hypothesis that a common polymorphism of methylenetetrahydrofolate reductase gene (C677T), which results in increased levels plasma homocysteine, may be putative risk factor for venous thromboembolism (VT). Sixty-five cases VT and 130 controls, both identified within framework an epidemiologic survey on thrombophilia, Vicenza Thrombophilia Arteriosclerosis (VITA) Project, were genotyped mutation. No was found carriers conclude screening C677T mutation should not recommended unselected patients with VT.