Interaction between hyperhomocysteinemia, mutated methylenetetrahydrofolatereductase (MTHFR) and inherited thrombophilic factors in recurrent venous thrombosis.
作者： Miranda BAJ KeiJzer , Martin Den Heijer , Henk J Blom , Gerard MJ Bos , Huub PJ Willems
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摘要: Venous thrombosis is a multicausal disease involving acquired and genetic factors. In this study we investigated possible interaction between hyperhomocysteinemia (fasting or postload) factor V Leiden prothrombin G20210A on the risk of recurrent venous thrombosis. We also looked at due to mutations in MTHFR-gene (C677T A1298C). performed case-control 171 patients with history 461 control subjects from general population. Hyperhomocysteinemia 6 h after an oral methionine load) was defined as homocysteine concentration above 90th percentile distributions group. The odds ratio (adjusted for age sex) 1.8 (95%CI: 1.1 3.0) fasting hyperhomocysteinemia, 5.1 3.0 8.6) 0.7 4.2) G20210A. found 14 3 controls both Leiden, which yielded 11.6 3.2 42.5). no relative MTHFR 677CT 1.6 2.4) 677TT 1.4 2.8). combined 18.7 3.3 108). conclude that are factors appeared high individuals who had
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