Expression and self-regulatory function of cardiac interleukin-6 during endotoxemia
作者： Hiroshi Saito , Cam Patterson , Zhaoyong Hu , Marschall S. Runge , Ulka Tipnis
DOI: 10.1152/AJPHEART.2000.279.5.H2241
关键词:
摘要: Interleukin (IL)-6 reportedly has negative inotropic and hypertrophic effects on the heart. Here, we describe endotoxin-induced IL-6 in heart that not previously been well characterized. An...
sci-hub.se 参考文章(30)
D Pennica, D V Goeddel, P W Gray, D Glaister, E Chen, Two interleukin 1 genes in the mouse: cloning and expression of the cDNA for murine interleukin 1 beta. Journal of Immunology. ,vol. 137, pp. 3644- 3648 ,(1986)
Peter C. HEINRICH, Iris BEHRMANN, Gerhard MÜLLER-NEWEN, Fred SCHAPER, Lutz GRAEVE, INTERLEUKIN-6-TYPE CYTOKINE SIGNALLING THROUGH THE GP130/JAK/STAT PATHWAY Biochemical Journal. ,vol. 334, pp. 297- 314 ,(1998) , 10.1042/BJ3340297
D. Remick, Kaizhi Guo, J. Del Castillo, Songmei Yin, T. R. Ulich, Endotoxin-induced cytokine gene expression in vivo. III. IL-6 mRNA and serum protein expression and the in vivo hematologic effects of IL-6. Journal of Immunology. ,vol. 146, pp. 2316- 2323 ,(1991)
H. Hirota, K. Yoshida, T. Kishimoto, T. Taga, CONTINUOUS ACTIVATION OF GP130, A SIGNAL-TRANSDUCING RECEPTOR COMPONENT FOR INTERLEUKIN 6-RELATED CYTOKINES, CAUSES MYOCARDIAL HYPERTROPHY IN MICE Proceedings of the National Academy of Sciences of the United States of America. ,vol. 92, pp. 4862- 4866 ,(1995) , 10.1073/PNAS.92.11.4862
Marianne Gwechenberger, Leonardo H. Mendoza, Keith A. Youker, Nikolaos G. Frangogiannis, C. Wayne Smith, Lloyd H. Michael, Mark L. Entman, Cardiac Myocytes Produce Interleukin-6 in Culture and in Viable Border Zone of Reperfused Infarctions Circulation. ,vol. 99, pp. 546- 551 ,(1999) , 10.1161/01.CIR.99.4.546
Z Xing, J Gauldie, G Cox, H Baumann, M Jordana, X F Lei, M K Achong, IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. Journal of Clinical Investigation. ,vol. 101, pp. 311- 320 ,(1998) , 10.1172/JCI1368
Shizuo Akira, Tadamitsu Kishimoto+, IL-6 and NF-IL6 in acute-phase response and viral infection Immunological Reviews. ,vol. 127, pp. 25- 50 ,(1992) , 10.1111/J.1600-065X.1992.TB01407.X
Uichi Ikeda, Fujio Ohkawa, Yoshitane Seino, Keiji Yamamoto, Yusuke Hidaka, Tadashi Kasahara, Tadashi Kawai, Kazuyuki Shimada, Serum interleukin 6 levels become elevated in acute myocardial infarction. Journal of Molecular and Cellular Cardiology. ,vol. 24, pp. 579- 584 ,(1992) , 10.1016/0022-2828(92)91042-4
Tadamitsu Kishimoto, Tetsuya Taga, Shizuo Akira, Cytokine signal transduction Cell. ,vol. 76, pp. 253- 262 ,(1994) , 10.1016/0092-8674(94)90333-6
K Youker, C W Smith, D C Anderson, D Miller, L H Michael, R D Rossen, M L Entman, Neutrophil adherence to isolated adult cardiac myocytes. Induction by cardiac lymph collected during ischemia and reperfusion. Journal of Clinical Investigation. ,vol. 89, pp. 602- 609 ,(1992) , 10.1172/JCI115626