Method for fluorescence analysis and fluorescence analyzer

作者: Takayuki Obara , Akira Maekawa , Nobutaka Kumazaki , Takuya Matsui , Satoshi Takahashi

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摘要: The present invention aims at reducing background noise derived from a substance that is in the vicinity of target such as DNA and protein attached to surface substrate without an effect on fluorescent dye labeling substance. has probe capable interacting with irradiated removing light evanescent field generated substrate. A foreign particle, which are non-specifically stuck substrate, decomposed by irradiation light. near almost no probe. It possible reduce suppress effects

参考文章(11)
Stephen Weibel, Robert M. Corn, Robert J. Hamers, Lloyd M. Smith, Matthew R. Lockett, Michael R. Shortreed, Bin Sun, Surface plasmon resonance compatible carbon thin films ,(2008)
Shiao-Chun Tu, James Briggs, Xiaolian Gao, Richard Willson, Susan Hardin, Methods for real-time single molecule sequence determination ,(2004)
Takayuki Obara, Akira Maekawa, Toshiro Saito, Kiyoyuki Kagii, Nucleic acid analyzing apparatus ,(2009)
Stephen G. Lipson, Shay Nimri, Boaz Ran, Doron Lipson, Ariel G. Notcovich, Ariel Lipson, Surface plasmon resonance sensor ,(2002)
H. Ruparel, L. Bi, Z. Li, X. Bai, D. H. Kim, N. J. Turro, J. Ju, Design and synthesis of a 3′-O-allyl photocleavable fluorescent nucleotide as a reversible terminator for DNA sequencing by synthesis Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 5932- 5937 ,(2005) , 10.1073/PNAS.0501962102
Mathieu Foquet, Kevan T. Samiee, Xiangxu Kong, Bidhan P. Chauduri, Paul M. Lundquist, Stephen W. Turner, Jake Freudenthal, Daniel B. Roitman, Improved fabrication of zero-mode waveguides for single-molecule detection Journal of Applied Physics. ,vol. 103, pp. 034301- ,(2008) , 10.1063/1.2831366
I. Braslavsky, B. Hebert, E. Kartalov, S. R. Quake, Sequence information can be obtained from single DNA molecules Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 3960- 3964 ,(2003) , 10.1073/PNAS.0230489100
Tsuyoshi Sonehara, Nobutaka Kumazaki, Takanobu Haga, Hirokazu Kato, Satoshi Takahashi, Fluorescence detection apparatus ,(2008)
Hitoshi Fuji Photo Film Co. Ltd. Shimizu, Sensor utilizing attenuated total reflection ,(2001)
David Ralin, Feimeng Zhou, William Rassman, Shubo Han, Method and apparatus for recognizing molecular compounds ,(2003)