The biochemical mechanism of selective heat sensitivity of cancer cells

摘要: Abstract Lysosomes from Novikoff hepatoma cells show, if compared to those normal or regenerating liver cells, a higher lability, as measured by the rate of release acid hydrolases. Moreover, in lysosomes neoplastic various enzymes at 38 and 43 °C follows non-homogeneous pattern. Neither intracellular lysosomal damage photolysis, nor intralysosomal inhibition hydrolases trypan blue modify onset respiration tumor elevated temperatures. It is concluded that specific heat sensitivity partially reflected level their membranes, but probably not primary mechanism cellular caused heat.