Dapsone-induced DRESS after infliximab-induced vasculitis: a case of cerebral infarction in the context of multiple drug reactions.

摘要: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening condition characterised by peripheral eosinophilia, rash multi-organ failure arising several weeks after exposure to the culprit medication. Although rare, DRESS triggered specific agents has been associated genetic polymorphisms more prevalent in different ethnic groups, including an association between dapsone-induced Human Leukocyte Antigen (HLA)-B:13*01, single nucleotide polymorphism those of Asian descent. drug-related vasculitis may affect any organ system central nervous (CNS), usually manifesting as encephalitis, meningitis or embolic cerebrovascular accidents related eosinophilic cardiac disease thrombosis. CNS much rarer complication drug reactions that manifest multifocal ischemia on neuroimaging. In circumstances vasculitides, treatment high-dose corticosteroids lead rapid improvement and, ultimately, resolution focal neurologic deficits.