Reduced cohesin destabilizes high-level gene amplification by disrupting pre-replication complex bindings in human cancers with chromosomal instability.
作者： Jiyeon Yun , Sang-Hyun Song , Jee-Youn Kang , Jinah Park , Hwang-Phill Kim
DOI: 10.1093/NAR/GKV933
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摘要: Gene amplification is a hallmark of cancer with chromosomal instability although the underlying mechanism by which altered copy numbers are maintained is largely unclear …
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