MicroRNAs Change the Landscape of Cancer Resistance
作者： Jun Zhu , Wei Zhu , Wei Wu
DOI: 10.1007/978-1-4939-7435-1_6
关键词:
摘要: One of the major challenges in cancer treatment is development drug resistance. It represents a obstacle to curing with constrained efficacy both conventional chemotherapy and targeted therapies, even recent immune checkpoint blockade therapy. Deciphering mechanisms resistance critical further understanding multifactorial pathways involved, developing more specific treatments. To date, numerous studies have reported potential role microRNAs (miRNAs) various MicroRNAs are family small noncoding RNAs that regulate gene expression by sequence-specific targeting mRNAs causing translational repression or mRNA degradation. More than 1200 validated human miRNAs been identified genome. While one miRNA can hundreds targets, single target also be affected multiple miRNAs. Evidence suggests dysregulation may involved acquisition resistance, thereby modulating sensitivity cells treatment. Therefore, manipulation an attractive strategy for effective individualized therapies through reprograming resistant network cells.
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