Plasma and muscle amino acid levels in relation to resting energy expenditure and inflammation in stable chronic obstructive pulmonary disease.

摘要: In patients with chronic obstructive pulmonary disease (COPD), muscle wasting can occur independently of fat loss, suggesting disturbances in protein metabolism. order to provide more insight amino-acid (AA) metabolism stable COPD, we examined arterial plasma and anterior tibialis AA levels, comparing 12 COPD eight age-matched healthy control subjects. We also studied relationships between the acute phase response as measured by lipopolysaccharide-binding (LBP), resting energy expenditure (REE). contrast findings diseases associated wasting, found increased glutamine (GLN) levels our patient group (mean ± SEM = 10,782 770 versus 7,844 293 μ mol/kg wet weight, p  < 0.01). Furthermore, arginine, ornithine, citrulline were significantly group, whereas glutamic acid was decreased. plasma, sum all (SumAA) decreased (2,595 65 v...