A Flexible Neural Analog Using Integrated Circuits

作者: Andrew S. French , Richard B. Stein

DOI: 10.1109/TBME.1970.4502739

关键词:

摘要: An electronic neural analog is described which contains variable absolute and relative refractory periods, two time constants, separate control of the ``accommodation'' to sub-threshold voltage changes ``adaptation'' produced by occurrence output pulses (spikes). The extensive use integrated-circuit operational amplifiers permits an accurate description input-output relationships over a wide range values for all parameters. This facilitates comparison results obtained both with data mathematical or digitally simulated models activity. effect white noise on interval histograms their parameters its when added other inputs. Noise disrupts phase-locked patterns sinusoidal stimuli averaged response may become smooth function in presence noise. Adaptation produce phase lead stimuli, while accommodation lag. Corresponding overshoots undershoots are seen square-wave

参考文章(21)
F. Jenik, Electronic neuron models as an aid to neurophysiological research. Ergebnisse der Biologie. ,vol. 25, pp. 206- 245 ,(1962) , 10.1007/978-3-642-94837-4_7
M. G. F. Fuortes, A. L. Hodgkin, Changes in time scale and sensitivity in the ommatidia ofLimulus The Journal of Physiology. ,vol. 172, pp. 239- 263 ,(1964) , 10.1113/JPHYSIOL.1964.SP007415
D. Noble, R. B. Stein, The threshold conditions for initiation of action potentials by excitable cells The Journal of Physiology. ,vol. 187, pp. 129- 162 ,(1966) , 10.1113/JPHYSIOL.1966.SP008079
A. L. Hodgkin, A. F. Huxley, A quantitative description of membrane current and its application to conduction and excitation in nerve The Journal of Physiology. ,vol. 117, pp. 500- 544 ,(1952) , 10.1113/JPHYSIOL.1952.SP004764
E. R. Lewis, An electronic model of neuroelectric point processes Kybernetik. ,vol. 5, pp. 30- 46 ,(1968) , 10.1007/BF00288896
Richard FitzHugh, Impulses and Physiological States in Theoretical Models of Nerve Membrane Biophysical Journal. ,vol. 1, pp. 445- 466 ,(1961) , 10.1016/S0006-3495(61)86902-6
F. F. Hiltz, Simulated Membrane Junctions and Additional Feedback Characteristics for an Artificial Neuron IEEE Transactions on Biomedical Engineering. ,vol. 12, pp. 94- 104 ,(1965) , 10.1109/TBME.1965.4502354
Wilfrid Rall, Electrophysiology of a dendritic neuron model. Biophysical Journal. ,vol. 2, pp. 145- 167 ,(1962) , 10.1016/S0006-3495(62)86953-7