Role of nonsteroidal anti-inflammatory drugs in the prevention of post-ERCP pancreatitis: a meta-analysis.
作者： Kui Zhao , Hui-Fen Dai , Xiao-Wen Wang
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摘要: BACKGROUND: The role of prophylactic nonsteroidal anti-inflammatory drugs (NSAIDs) for reduction pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) is debated. We performed a meta-analysis all published randomized controlled trials to evaluate the efficacy NSAIDs in prevention post-ERCP pancreatitis. DATA SOURCES: Searches were conducted databases PubMed, EMBASE and Cochrane Library. Six clinical that fulfilled inclusion criteria addressed questions this analysis further assessed. Data extracted by two independent observers according predetermined criteria. RESULTS: risk was lower NSAID group than placebo (OR: 0.46, 95% CI: 0.32 0.65, P＜0.0001). Two hours ERCP, administration associated with serum amylase level (WMD: -91.09, -149.78 -32.40, P=0.002), but there no difference mean 24-hour values -379.00, -805.75 47.76, P=0.08). No deaths or NSAID-related complications noted. CONCLUSIONS: Prophylactic can reduce incidence pancreatitis; patients undergoing ERCP recommended. Further are required before its introduction into routine care.
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