Effects of pancreatic enzyme preparations on erythrocyte glutathione peroxidase activities and plasma selenium concentrations in cystic fibrosis

摘要: To substitute for exocrine pancreatic insufficiency, patients with cystic fibrosis (CF) take enzymes (PE) originating from porcine pancreas. Five different enzyme preparations used by our contained 0.5–1.4 μg selenium per g tablet. In taking PE in doses that were gradually increased to improve fat absorption during a 48-month period, the effects of dose on erythrocyte selenium-dependent glutathione peroxidase (SeGSH-Px) activities and plasma concentrations studied. At baseline, SeGSH-Px significantly lower (p = .01), while did not differ between healthy subjects. When and, consequently, intake was increased, < .001) .02) increased. Changes initial 8 months correlated those (r 0.67, p .001). Plasma plateaued at 12 so 36 months, when had reached similar 48 took an average lipase 17400 U · kg−1 d−1 0.53 d−1. We conclude content has significant effect activity CF. This form supply needs be taken into account supplements are given