Bone mass and mineralization in osteogenesis imperfecta

摘要: The main clinical features of osteogenesis imperfecta (OI) are low bone mass and high fragility. While the decrease in is generally regarded as an indicator disease severity, fragility appears hallmark disorder. Bone has a multiscale hierarchical structural organization optimized to resist fractures. In OI, modifications at molecular level affect total mechanical integrity bone. A specific characteristic OI that matrix abnormally mineralized independently underlying mutation or severity. increased mineralization affects material quality, leading stiffness brittleness making prone purpose this review give further insights on discuss advantages pitfalls invasive noninvasive imaging techniques.