Noninvasive imaging of bone microarchitecture

摘要: The noninvasive quantification of peripheral compartment-specific bone microarchitecture is feasible with high-resolution quantitative computed tomography (HR-pQCT) and magnetic resonance imaging (HR-MRI). In addition to classic morphometric indices, both techniques provide a suitable basis for virtual biomechanical testing using finite element (FE) analyses. Methodical limitations, parameter definition, motion artifacts have be considered achieve optimal data interpretation from studies. With increasing availability in vivo techniques, special emphasis should put on quality control including multicenter, cross-site validations. Importantly, conclusions interventional studies investigating the effects antiosteoporotic drugs drawn care, ideally involving scientists, translational researchers, clinicians.