Sleep quality and body mass index: a co-twin study

摘要: Summary There is a consistent relationship between body mass index and sleep quality. However, the directionality possible confounding factors of this are unclear. Our aim to confirm association quality index, independent genetic confounding, as well provide some indirect inferences about association. The co-twin study design was used analyse index–sleep in sample 2150 twins. We selected two parallel sub-samples twins discordant for (n = 430 pairs), or (n = 316 pairs). Sleep showed an inverse (b = 0.056, P = 0.032) global sample. When were selected, maintained similar effect size statistical significance, at all levels case–control analysis (all pairs b = 0.173, P < 0.001; dizygotic b = 0.174, P = 0.002; monozygotic P = 0.050). Nevertheless, when twin on basis their discordance quality, appeared weaker lost significance (b = 0.021, P = 0.508). analyses including only (b = 0.028, P = 0.526) (b = 0.001, P = 0.984) produced non-significant results. results even after applying high control, factors. Moreover, suggests relationship, such that would strongly affect while opposite be less robust non-clinical samples.