Treatment of spontaneous and chemically induced EEG paroxysms in the Fischer-344 rat with traditional antiepileptic drugs or AED+CGP 35348 polytherapy
作者： Glenn D Ritchie , Mary E Hulme , John Rossi
DOI: 10.1016/S0278-5846(03)00144-1
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摘要: Abstract Twenty-four Fischer-344 rats implanted with cortical electroencephalograph (EEG) electrodes were evaluated for frequency, duration, and mean duration (duration/frequency) of both spontaneous chemically induced spike-and-wave discharges (SWDs) during earlier later adulthood. rats, exhibiting a low level SWDs adulthood, progressed to exhibit significantly larger number The convulsant trimethylolpropane phosphate (TMPP), known antagonize the GABAA inhibitory system through blockade chloride channel, or increased in every rat tested. Spontaneous eliminated reduced by several drugs used control human absence seizures. gamma-aminobutyric acid (GABA)B antagonist CGP 35348 EEG paroxysms; as polytherapy traditional antiabsence treatments improved TMPP-induced It would appear that provides an excellent research alternative use genetically selected rodent strains investigation progression absencelike epilepsy aging, induction toxicant exposures, treatment paroxysms.
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