Aminoacyl-tRNA synthetases and their inhibitors as a novel family of antibiotics
作者： S. Kim , S. W. Lee , E.-C. Choi , S. Y. Choi
DOI: 10.1007/S00253-003-1243-5
关键词:
摘要: The emergence of multidrug-resistant strains pathogenic microorganisms and the slow progress in new antibiotic development has led recent years to a resurgence infectious diseases that threaten well-being humans. result many becoming immune major antibiotics means fighting off infection by these pathogens is more difficult. best strategy get around drug resistance discover targets, taking advantage abundant information was recently obtained from genomic proteomic research, explore them for development. In this regard, aminoacyl-tRNA synthetases (ARSs) provide promising platform develop novel show no cross-resistance other classical antibiotics. During last few there been comprehensive attempt find compounds can specifically target ARSs inhibit bacterial growth. review, current status ARS inhibitors will be briefly summarized, based on their chemical structures working mechanisms.
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