Uncovering a Mineralocorticoid Receptor–Dependent Adipose–Vascular Axis: Implications for Vascular Dysfunction in Obesity?

摘要: Obesity, insulin resistance, and type 2 diabetes mellitus (T2DM) are associated with increased levels of aldosterone activation cardiovascular mineralocorticoid receptors (MRs) contributing to hypertension disease (CVD) (1). Large randomized controlled trials such as the Randomized Aldactone Evaluation Study (RALES), Epleronone Post-Acute Myocardial Infarction Heart Failure Efficacy Survival (EPHESUS), Eplerenone in Mild Patients Hospitalization (EMPHASIS-HF) have demonstrated CVD-related mortality morbidity benefits MR antagonists, further implicating signaling a key mediator CVD (2). The actions kidney increase renal fibrosis blood pressure is well known; however, recent research suggests that inappropriate extrarenal vascular endothelial cells (ECs), smooth muscle (VSMCs), immune cells, adipocytes promotes T2DM, (1,3,4). For example, association obesity perivascular visceral adipose tissue (PVAT VAT) dysfunctional, part, because (3). Furthermore, PVAT VAT secrete aldosterone, ligand for MRs this (3, …