Subventricular zone stem cells are heterogeneous with respect to their embryonic origins and neurogenic fates in the adult olfactory bulb.

作者: K. M. Young , M. Fogarty , N. Kessaris , W. D. Richardson

DOI: 10.1523/JNEUROSCI.0476-07.2007

关键词:

摘要: We determined the embryonic origins of adult forebrain subventricular zone (SVZ) stem cells by Cre-lox fate mapping in transgenic mice. found that all parts telencephalic neuroepithelium, including medial ganglionic eminence and lateral (LGE) cerebral cortex, contribute multipotent, self-renewing to SVZ. Descendants LGE cortex settle ventral dorsal aspects dorsolateral SVZ, respectively. Both populations new (5-bromo-2'-deoxyuridine-labeled) tyrosine hydroxylase- calretinin-positive interneurons olfactory bulb. However, calbindin-positive glomeruli were generated exclusively LGE-derived cells. Thus, different SVZ have origins, colonize generate neuronal progeny, suggesting some patterning are preserved This could important implications for design endogenous cell-based therapies future.

参考文章(51)
Paolo Malatesta, Michael A. Hack, Eva Hartfuss, Helmut Kettenmann, Wolfgang Klinkert, Frank Kirchhoff, Magdalena Götz, Neuronal or Glial Progeny: Regional Differences in Radial Glia Fate Neuron. ,vol. 37, pp. 751- 764 ,(2003) , 10.1016/S0896-6273(03)00116-8
Stephen C. Noctor, Alexander C. Flint, Tamily A. Weissman, Winston S. Wong, Brian K. Clinton, Arnold R. Kriegstein, Dividing precursor cells of the embryonic cortical ventricular zone have morphological and molecular characteristics of radial glia. The Journal of Neuroscience. ,vol. 22, pp. 3161- 3173 ,(2002) , 10.1523/JNEUROSCI.22-08-03161.2002
Angela Gritti, Luca Bonfanti, Fiona Doetsch, Isabelle Caille, Arturo Alvarez-Buylla, Daniel A. Lim, Rossella Galli, Jose Manuel Garcia Verdugo, Daniel G. Herrera, Angelo L. Vescovi, Multipotent Neural Stem Cells Reside into the Rostral Extension and Olfactory Bulb of Adult Rodents The Journal of Neuroscience. ,vol. 22, pp. 437- 445 ,(2002) , 10.1523/JNEUROSCI.22-02-00437.2002
Sanjay S. Magavi, Blair R. Leavitt, Jeffrey D. Macklis, Induction of neurogenesis in the neocortex of adult mice. Nature. ,vol. 405, pp. 951- 955 ,(2000) , 10.1038/35016083
Katsuko Kosaka, Yusuke Aika, Kazunori Toida, Claus W. Heizmann, Willi Hunziker, David M. Jacobowitz, Ikuko Nagatsu, Peter Streit, Theo J. Visser, Toshio Kosaka, Chemically defined neuron groups and their subpopulations in the glomerular layer of the rat main olfactory bulb Neuroscience Research. ,vol. 23, pp. 73- 88 ,(1995) , 10.1016/0168-0102(95)90017-9
Natalie D Bull, Perry F Bartlett, The adult mouse hippocampal progenitor is neurogenic but not a stem cell. The Journal of Neuroscience. ,vol. 25, pp. 10815- 10821 ,(2005) , 10.1523/JNEUROSCI.3249-05.2005
Nikki L Sundholm-Peters, Helen K. C Yang, Gwendolyn E Goings, Avery S Walker, Francis G Szele, Subventricular zone neuroblasts emigrate toward cortical lesions. Journal of Neuropathology and Experimental Neurology. ,vol. 64, pp. 1089- 1100 ,(2005) , 10.1097/01.JNEN.0000190066.13312.8F
L. Decker, C. Delarasse, K. Goude, B. Nait-Oumesmar, R. Liblau, D. Pham-Dinh, A. B.-V. Evercooren, N. Picard-Riera, Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 13211- 13216 ,(2002) , 10.1073/PNAS.192314199
K. M. Young, T. D. Merson, A. Sotthibundhu, E. J. Coulson, P. F. Bartlett, p75 neurotrophin receptor expression defines a population of BDNF-responsive neurogenic precursor cells. The Journal of Neuroscience. ,vol. 27, pp. 5146- 5155 ,(2007) , 10.1523/JNEUROSCI.0654-07.2007