Promising prognostic markers of preeclampsia: new avenues in waiting.

作者: Anshul Jadli , Nitika Sharma , Kaizad Damania , Purnima Satoskar , Vandana Bansal

DOI: 10.1016/J.THROMRES.2015.05.011

关键词:

摘要: Preeclampsia is a pregnancy related condition identified by hypertension and either proteinuria or end-organ dysfunction after 20(th) week of gestation complicates 2-8% pregnancies worldwide. Enigmatic pathophysiology multi-system involvement hinder accurate identification clinical management patients. Inadequate trophoblast invasion subsequent inflammatory response have been implicated in the onset PE. In absence effective treatment preeclampsia except delivery, recent research has focused on specific sensitive biomarkers for early prediction Several angiogenic, anti-angiogenic, inflammatory, biophysical (mean arterial pressure uterine artery Doppler) biomarkers, alone combination, proposed but limited predictive values hindered their use settings. Current review summarizes some relatively new such as corin, copeptin, microparticles miRNA, prognostic efficiency which are analyzed associated disorders recently discovered.

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