Utilization of fluorescence in situ hybridization in the diagnosis of 230 mesenchymal neoplasms: an institutional experience.
作者： Erinn Downs-Kelly , John R. Goldblum , Munir R. Tanas , Brian P. Rubin , Raymond R. Tubbs
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摘要: Abstract Context—Mesenchymal neoplasms harbor characteristic translocations and amplification of gene regions amenable to evaluation by fluorescence in situ hybridization (FISH). Objective—To determine the utility FISH diagnosis mesenchymal neoplasms. Design—Two hundred thirty soft tissue cases analyzed were reviewed retrospectively. Results—Morphologic patterns where was used included high-grade round cell sarcomas (n = 67), nonmyogenic spindle 40), low-grade myxoid 34), adipocytic 20), melanocytic 19). Fifty did not fit into previously mentioned categories. SYT (96% monophasic synovial positive; 0% malignant peripheral nerve sheath tumor positive) DDIT3 (100% myxoid/round liposarcomas; no other neoplasm very sensitive specific. EWSR1 specific differential (8...
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Munir R. Tanas, John R. Goldblum, Fluorescence in situ hybridization in the diagnosis of soft tissue neoplasms: a review Advances in Anatomic Pathology. ,vol. 16, pp. 383- 391 ,(2009) , 10.1097/PAP.0B013E3181BB6B86
Erinn Downs-Kelly, John R. Goldblum, Raj M. Patel, Sharon W. Weiss, Andrew L. Folpe, Fredrick Mertens, Marybeth Hartke, Raymond R. Tubbs, Marek Skacel, The utility of fluorescence in situ hybridization (FISH) in the diagnosis of myxoid soft tissue neoplasms The American Journal of Surgical Pathology. ,vol. 32, pp. 8- 13 ,(2008) , 10.1097/PAS.0B013E3181578D5A
Karen C. Arden, Michael J. Anderson, Friedrich Graf Finckenstein, Suzanne Czekay, Webster K. Cavenee, Detection of the t(2;13) chromosomal translocation in alveolar rhabdomyosarcoma using the reverse transcriptase-polymerase chain reaction. Genes, Chromosomes and Cancer. ,vol. 16, pp. 254- 260 ,(1996) , 10.1002/(SICI)1098-2264(199608)16:4<254::AID-GCC5>3.0.CO;2-X
Jean-Michel Coindre, Isabelle Hostein, Jean Benhattar, Cathy Lussan, Janine Rivel, Louis Guillou, Malignant peripheral nerve sheath tumors are t(X;18)-negative sarcomas. Molecular analysis of 25 cases occurring in neurofibromatosis type 1 patients, using two different RT-PCR-based methods of detection. Modern Pathology. ,vol. 15, pp. 589- 592 ,(2002) , 10.1038/MODPATHOL.3880570
Fredrik Mertens, Christopher D M Fletcher, Cristina R Antonescu, Jean-Michel Coindre, Maurizio Colecchia, Henryk A Domanski, Erinn Downs-Kelly, Cyril Fisher, John R Goldblum, Louis Guillou, Robin Reid, Juan Rosai, Raf Sciot, Nils Mandahl, Ioannis Panagopoulos, Clinicopathologic and molecular genetic characterization of low-grade fibromyxoid sarcoma, and cloning of a novel FUS/CREB3L1 fusion gene. Laboratory Investigation. ,vol. 85, pp. 408- 415 ,(2005) , 10.1038/LABINVEST.3700230
Frederic G Barr, Jane Chatten, Celina M D'Cruz, Albert E Wilson, Lauren E Nauta, Lynn M Nycum, Jaclyn A Biegel, Richard B Womer, Molecular Assays for Chromosomal Translocations in the Diagnosis of Pediatric Soft Tissue Sarcomas JAMA: The Journal of the American Medical Association. ,vol. 273, pp. 553- 557 ,(1995) , 10.1001/JAMA.1995.03520310051029
Robert S Bridge, Veena Rajaram, Louis P Dehner, John D Pfeifer, Arie Perry, Molecular diagnosis of Ewing sarcoma/primitive neuroectodermal tumor in routinely processed tissue: a comparison of two FISH strategies and RT-PCR in malignant round cell tumors. Modern Pathology. ,vol. 19, pp. 1- 8 ,(2006) , 10.1038/MODPATHOL.3800486
Nicolas Sirvent, Jean-Michel Coindre, Georges Maire, Isabelle Hostein, Frédérique Keslair, Louis Guillou, Dominique Ranchere-Vince, Philippe Terrier, Florence Pedeutour, Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. The American Journal of Surgical Pathology. ,vol. 31, pp. 1476- 1489 ,(2007) , 10.1097/PAS.0B013E3180581FFF
Clelia Tiziana Storlazzi, Fredrik Mertens, Nils Mandahl, David Gisselsson, Margareth Isaksson, Pelle Gustafson, Henryk A. Domanski, Ioannis Panagopoulos, A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. Genes, Chromosomes and Cancer. ,vol. 37, pp. 195- 200 ,(2003) , 10.1002/GCC.10210
Joshua Weaver, Erinn Downs-Kelly, John R Goldblum, Sondra Turner, Sucheta Kulkarni, Raymond R Tubbs, Brian P Rubin, Marek Skacel, Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms Modern Pathology. ,vol. 21, pp. 943- 949 ,(2008) , 10.1038/MODPATHOL.2008.84