Therapeutic implications of tumor interstitial acidification

摘要: Interstitial acidification is a hallmark of solid tumor tissues resulting from the combination different factors, including cellular buffering systems, defective tissue perfusion and high rates metabolism. Besides contributing to pathogenesis promoting progression, acidosis constitutes an important intrinsic extrinsic mechanism modulating therapy sensitivity drug resistance. In fact, pharmacological properties anticancer drugs can be affected not only by structure organization but also distribution interstitial pH. The acidic environment believed create chemical barrier that limits effects activity many drugs. this review article we will discuss general protumorigenic acidosis, role in modulation therapeutic efficacy potential strategies overcome pH-dependent therapy-resistance.