Tool from traditional medicines is useful for health-medication: Bezoar Bovis and taurine.

摘要: Bezoar Bovis (BB:dried cattle gallbladder stones) has been used empirically in Asia for over 3000 years to treat heart and liver disorders. Yet its therapeutic potential remains unexplored by Western researchers. The aim of this study clarify the actions BB on cultured cardiomyocytes identify active component(s). is a component 98.7% Japanese counter (OTC) cardioactive drugs. water-extract exhibits protection action against arrhythmias produced low Ca2+ high medium. On other hand, Ca(2+)-antagonist, verapamil, did not suppress that developed cell culture. Rather, it aggravated beating status cardiomyocytes. major constituents extract are bile salts (cholate, deoxycholate, taurocholate) amino acids (taurine, cysteine, leucine, isoleucine). Most cells incubated with morphological damage. However, one extract, taurine, was effective protecting abnormal pattern induced Ca2+. Since beta-alanine, an inhibitor taurine transport, antagonized protective effects both likely effect partly mediated taurine.