Concurrence of TDP-43, tau and α-synuclein pathology in brains of Alzheimer's disease and dementia with Lewy bodies
作者： Shinji Higashi , Eizo Iseki , Ryoko Yamamoto , Michiko Minegishi , Hiroaki Hino
DOI: 10.1016/J.BRAINRES.2007.09.048
关键词:
摘要: TAR-DNA-binding protein 43 (TDP-43) has been identified as a major component protein of ubiquitin-positive inclusions in brains from patients with frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis. To obtain the precise prevalence of TDP-43 pathology in neurodegenerative disorders, we examined brains from patients with tauopathies and synucleinopathies as well as FTLD-U using immunohistochemical analysis. Consequently, TDP-43-positive inclusions within neurons …
elsevier.com
sci-hub.se 参考文章(48)
Yuko Saito, Akiko Kawashima, Nyoka N. Ruberu, Hideo Fujiwara, Shunichi Koyama, Motoji Sawabe, Tomio Arai, Hiroshi Nagura, Hiroshi Yamanouchi, Masato Hasegawa, Takeshi Iwatsubo, Shigeo Murayama, Accumulation of Phosphorylated α-Synuclein in Aging Human Brain Journal of Neuropathology and Experimental Neurology. ,vol. 62, pp. 644- 654 ,(2003) , 10.1093/JNEN/62.6.644
Mike Hutton, Corinne L. Lendon, Patrizia Rizzu, Matt Baker, Susanne Froelich, Henry Houlden, Stuart Pickering-Brown, Sumi Chakraverty, Adrian Isaacs, Andrew Grover, Jennifer Hackett, Jennifer Adamson, Sarah Lincoln, Dennis Dickson, Peter Davies, Ronald C. Petersen, Martijn Stevens, Esther de Graaff, Erwin Wauters, Jeltje van Baren, Marcel Hillebrand, Marijke Joosse, Jennifer M. Kwon, Petra Nowotny, Lien Kuei Che, Joanne Norton, John C. Morris, Lee A. Reed, John Trojanowski, Hans Basun, Lars Lannfelt, Michael Neystat, Stanley Fahn, Francis Dark, Tony Tannenberg, Peter R. Dodd, Nick Hayward, John B. J. Kwok, Peter R. Schofield, Athena Andreadis, Julie Snowden, David Craufurd, David Neary, Frank Owen, Ben A. Oostra, John Hardy, Alison Goate, John van Swieten, David Mann, Timothy Lynch, Peter Heutink, Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17 Nature. ,vol. 393, pp. 702- 705 ,(1998) , 10.1038/31508
Eizo Iseki, Takehiko Matsumura, Wami Marui, Hiroaki Hino, Toshinari Odawara, Naoya Sugiyama, Kyoko Suzuki, Hajime Sawada, Tetsuaki Arai, Kenji Kosaka, Familial frontotemporal dementia and parkinsonism with a novel N296H mutation in exon 10 of the tau gene and a widespread tau accumulation in the glial cells. Acta Neuropathologica. ,vol. 102, pp. 285- 292 ,(2001) , 10.1007/S004010000333
Mark S. Forman, Ian R. Mackenzie, Nigel J. Cairns, Eric Swanson, Philip J. Boyer, David A. Drachman, Bharati S. Jhaveri, Jason H. Karlawish, Alan Pestronk, Thomas W. Smith, Pang-Hsien Tu, Giles D. J. Watts, William R. Markesbery, Charles D. Smith, Virginia E. Kimonis, Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations. Journal of Neuropathology and Experimental Neurology. ,vol. 65, pp. 571- 581 ,(2006) , 10.1097/00005072-200606000-00005
Emanuele Buratti, Thilo Dörk, Elisabetta Zuccato, Franco Pagani, Maurizio Romano, Francisco E Baralle, Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping The EMBO Journal. ,vol. 20, pp. 1774- 1784 ,(2001) , 10.1093/EMBOJ/20.7.1774
Jennifer Murphy, Roland Henry, Catherine Lomen-Hoerth, Establishing Subtypes of the Continuum of Frontal Lobe Impairment in Amyotrophic Lateral Sclerosis JAMA Neurology. ,vol. 64, pp. 330- 334 ,(2007) , 10.1001/ARCHNEUR.64.3.330
D. Neary, J. S. Snowden, L. Gustafson, U. Passant, D. Stuss, S. Black, M. Freedman, A. Kertesz, P. H. Robert, M. Albert, K. Boone, B. L. Miller, J. Cummings, D. F. Benson, Frontotemporal lobar degeneration A consensus on clinical diagnostic criteria Neurology. ,vol. 51, pp. 1546- 1554 ,(1998) , 10.1212/WNL.51.6.1546
M. G. Spillantini, J. R. Murrell, M. Goedert, M. R. Farlow, A. Klug, B. Ghetti, Mutation in the tau gene in familial multiple system tauopathy with presenile dementia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 7737- 7741 ,(1998) , 10.1073/PNAS.95.13.7737
C. Kersaitis, G. M. Halliday, J. H. Xuereb, R. Pamphlett, T. H. Bak, J. R. Hodges, J. J. Kril, Ubiquitin-positive inclusions and progression of pathology in frontotemporal dementia and motor neurone disease identifies a group with mainly early pathology. Neuropathology and Applied Neurobiology. ,vol. 32, pp. 83- 91 ,(2006) , 10.1111/J.1365-2990.2005.00704.X
Manuela Neumann, Deepak M Sampathu, Linda K Kwong, Adam C Truax, Matthew C Micsenyi, Thomas T Chou, Jennifer Bruce, Theresa Schuck, Murray Grossman, Christopher M Clark, Leo F McCluskey, Bruce L Miller, Eliezer Masliah, Ian R Mackenzie, Howard Feldman, Wolfgang Feiden, Hans A Kretzschmar, John Q Trojanowski, Virginia M-Y Lee, Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis Science. ,vol. 314, pp. 130- 133 ,(2006) , 10.1126/SCIENCE.1134108