Therapeutic effects of sericin on diabetic keratopathy in Otsuka Long-Evans Tokushima Fatty rats.
作者： Noriaki Nagai , Yoshimasa Ito
关键词:
摘要: An Otsuka Long-Evans Tokushima Fatty (OLETF) rat provides a useful model for studies to develop corneal wound healing drugs use in diabetic keratopathy resulting from type 2 diabetes mellitus. We investigated the effects of sericin on OLETF rats. Corneal wounds were prepared by removal epithelium and documented using TRC-50X. Sericin was instilled into eyes rats five times day following abrasion. The plasma levels glucose, triglycerides, cholesterol insulin 38 wk old significantly higher than normal control (LETO rats), rate slower rat, probably due suppression cell migration proliferation caused high glucose levels. with saline showed almost complete 72 h after epithelial On other hand, instillation has potent effect promoting size reduction at 48 may be an effective safe drug promote keratopathy.
sci-hub.st 参考文章(58)
Stanley Cohen, Wilkes H. Davis, Patrick C. Ho, James H. Elliott, Kinetics of Corneal Epithelial Regeneration and Epidermal Growth Factor Investigative Ophthalmology & Visual Science. ,vol. 13, pp. 804- 809 ,(1974)
I K Gipson, S Spurr-Michaud, M A Stepp, Integrins in the wounded and unwounded stratified squamous epithelium of the cornea. Investigative Ophthalmology & Visual Science. ,vol. 34, pp. 1829- 1844 ,(1993)
S. C. G. Tseng, J. J. Y. Chen, Corneal epithelial wound healing in partial limbal deficiency. Investigative Ophthalmology & Visual Science. ,vol. 31, pp. 1301- 1314 ,(1990)
James D. Zieske, Audrey E. K. Hutcheon, Nancy C. Joyce, Eui–Hong Chung, Synchronization of the G1/S transition in response to corneal debridement. Investigative Ophthalmology & Visual Science. ,vol. 40, pp. 1952- 1958 ,(1999)
R A Kimsey, H R Taylor, Corneal epithelial basement membrane changes in diabetes. Investigative Ophthalmology & Visual Science. ,vol. 20, pp. 548- 553 ,(1981)
J Friend, R A Thoft, The X, Y, Z hypothesis of corneal epithelial maintenance. Investigative Ophthalmology & Visual Science. ,vol. 24, pp. 1442- 1443 ,(1983)
SABINE WERNER, RICHARD GROSE, Regulation of Wound Healing by Growth Factors and Cytokines Physiological Reviews. ,vol. 83, pp. 835- 870 ,(2003) , 10.1152/PHYSREV.2003.83.3.835
Joon Pio Hong, Heun Don Jung, Yun Wha Kim, Recombinant human epidermal growth factor (EGF) to enhance healing for diabetic foot ulcers. Annals of Plastic Surgery. ,vol. 56, pp. 394- 400 ,(2006) , 10.1097/01.SAP.0000198731.12407.0C
Norihisa KATO, Seiji SATO, Atsushi YAMANAKA, Hideyuki YAMADA, Naozumi FUWA, Masakazu NOMURA, Silk Protein, Sericin, Inhibits Lipid Peroxidation and Tyrosinase Activity Bioscience, Biotechnology, and Biochemistry. ,vol. 62, pp. 145- 147 ,(1998) , 10.1271/BBB.62.145
Judith Friend, Yasuo Ishíi, Richard A. Thoft, Corneal Epithelial Changes in Diabetic Rats Ophthalmic Research. ,vol. 14, pp. 269- 278 ,(1982) , 10.1159/000265202